Janoshik-Certified
Every Batch Third-Party Tested
Latest COAs Available
Research Grade Purity
Research Use Only
Janoshik-Certified
Every Batch Third-Party Tested
Latest COAs Available
Research Grade Purity
Research Use Only
PT-141 10MG
RM180.00
C50H68N14O10
A cyclic melanocortin receptor agonist investigated for sexual arousal and central nervous system research.
In stock — ships from Malaysia
Description
Description
Key Research Findings
- Two phase 3 randomised trials in premenopausal women with hypoactive sexual desire disorder, reported in Obstetrics & Gynecology (2019).
- Randomised, placebo-controlled dose-finding trial in premenopausal women with female sexual dysfunction, published in Women’s Health (2016).
- A central rather than vascular mechanism — melanocortin agonism acts on brain pathways, distinct from the peripheral blood-flow mechanism of PDE-5 inhibitors.
- Preclinical characterisation — selective facilitation of sexual solicitation behaviour in female rats via melanocortin receptor agonism (PNAS, 2004).
Published clinical trial results, provided as scientific background only. They describe research in clinical populations and do not indicate any approved or intended use of this product.
Overview
- A synthetic cyclic peptide of seven amino acids, structurally derived from α-melanocyte-stimulating hormone (α-MSH).
- Developed from the earlier compound Melanotan-II.
- Acts on melanocortin receptors in the central nervous system rather than on blood vessels.
- Studied principally in the context of sexual desire and arousal, alongside wider melanocortin receptor biology.
- Supplied as a 10 mg lyophilised vial for laboratory research only.
How It Works
- MC4R agonism — the primary target is the melanocortin-4 receptor, with lesser activity at MC1R, MC3R and MC5R.
- Where MC4R sits — densely expressed in central nervous system regions involved in sexual function, including the hypothalamus.
- Central, not peripheral — the pathway is neurological. This distinguishes it from PDE-5 inhibitors, which act on blood flow in peripheral tissue.
- Wider melanocortin biology — MC4R also participates in appetite and energy expenditure regulation, which is why the receptor is studied well beyond sexual function.
Research Effects
Human Clinical Trials
Hypoactive Sexual Desire Disorder
Assessed in two phase 3 randomised controlled trials in premenopausal women.
Human Clinical Trials
Sexual Arousal Response
Dose-finding randomised, placebo-controlled trial data in premenopausal women with sexual dysfunction.
Lab & Animal Studies
Melanocortin Pathway Signalling
MC4R agonism and downstream central signalling characterised in receptor and animal studies.
Lab & Animal Studies
Sexual Behaviour Models
Selective facilitation of sexual solicitation behaviour reported in female rats.
Lab & Animal Studies
Erectile Function Research
Investigated in preclinical models, via a central mechanism distinct from vasoactive agents.
Lab & Animal Studies
Appetite & Energy Expenditure
MC4R involvement in feeding behaviour and energy balance studied in animal models.
Human Clinical Trials — reported in published human trial dataLab & Animal Studies — laboratory or animal studies only
Amino Acid Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OHA cyclic heptapeptide analogue of α-MSH. The ring structure, formed by a bond between the aspartate and lysine side chains, holds the peptide in a fixed shape and makes it far more resistant to breakdown than a linear sequence.
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Research use only. Sold strictly for research and laboratory use only. Not for human or animal consumption. Not for diagnostic, therapeutic or clinical use. Citations describe research contexts and do not imply approval for human use.
